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Bupropion is really an example of an antidepressant having an amphetamine-like structure comparable to ephedrine, and it truly is an NDRI. Its motion bears additional resemblance to amphetamine than to fluoxetine in that its Main mode of therapeutic action entails norepinephrine also to a lesser degree dopamine, but In addition it releases some serotonin from presynaptic clefts. It should not be employed with ephedrine, as it may improve the chance of Unintended effects.

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